A good place is to consider the key feature of the genre we are supposed to deploy as the first place for us to consider where to start thinking about communicating significance of a narrative to our audience.
Keep in special mind that it is your responsibility to “make clear” why or how this story has significance to an audience.
This can take the form, when it comes to significance, of being as simple as:
Personal significance: Where what you communicate is reflective and where you communicate to your audience how the narrative has meaning to you personally
Larger significance: Where you communicate a message in your story and explicitly point it out to your audience about how it has a larger meaning anyone can take away as important
Both: It can be both 1 and 2.
To better help you out here, let us look at an example from Shannon Nichols short essay “Proficiency” for some guidance: